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Side Effects of This Medicine
More common side effects may include:
- Dizziness, dry mouth, fatigue, headache, light-headedness, nausea, nervousness, unusual excitement
Less common or rare side effects may include:
- Anger/hostility, blurred vision, bone aches/pain, confusion, constipation, decreased concentration, depression, diarrhea, fast, fluttery heartbeat, incoordination, muscle pain/aches, numbness,
pain or weakness in hands or feet, rapid heartbeat, rash, restlessness, stomach and abdominal upset, sweating/clamminess, tingling or pins and needles, tremor, urinary incontinence, vomiting, weakness
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Proper Use of This Medicine
The recommended initial dose is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maxim
um daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.
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Adverse Effects
CNS:
Dizziness, headache, drowsiness, lightheadedness, insomnia, fatigue, nervousness, decreased concentration, excitement, depression, confusion, nightmares/vivid dreams, anger/hostility. Infrequ
ently (<1%) depersonalization, noise intolerance, euphoria/feeling high, dissociative reaction, fear, loss of interest, dysphoria, hallucinations, seizures, suicidal thoughts. Rarely, slurred speech,
claustrophobia, cold intolerance, stupor, psychosis.
Neurologic:
Paresthesia, weakness, incoordination, tremor, numbness. Infrequently, muscle cramps and spasms, rigid/stiff muscles, involu
ntary movements, akathisia, slowed reaction time. Rarely, tingling of limbs, stiff neck, rigidity of jaw, ataxia.
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Significant Interactions:
In laboratory studies in healthy volunteers, buspirone in doses up to 20 mg did not potentiate the psychomotor impairment produced by relatively modest doses of alcohol. However, decreased contentedne
ss or dysphoria was observed with a combination of alcohol and a 20 mg single dose of buspirone. Since no data are available on concomitant use of higher doses of buspirone and alcohol, it is prudent
to advise patients to avoid alcohol during buspirone therapy.
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Symptoms of overdose may include:
Any medication taken in excess can have serious consequences. If you suspect an overdose of BuSpar, seek medical attention immediately.
The symptoms of BuSpar overdose may include:
- Di
zziness, drowsiness, nausea or vomiting, severe stomach upset, unusually small pupils.
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Description
The mechanism of action of BUSPAR is not clearly known. BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relax
ant effects. It also lacks the prominent sedative effect that is associated with benzodiazepines
In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors
in the brain that mediate arousal). BUSPAR has no significant affinity for benzodiazepine receptors in the brain.
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