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adverse effects of botanical and non-botanical ephedrine products. june weintraub. ?1997 by june weintraub. all rights reserved. introduction. species of the genus ephedra are the botanical source for
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Since early 1990, the FDA has issued numerous warnings to consumers of diet products and supplements containing Ephedrine, Ephedra or Ma Huang. In fact, in November 1994, the FDA informed Alliance U.S
.A. that its Natureˇ¦s Nutritional Formula One posed a potential health hazard and was in violation of federal laws designed to protect the public health and even issued a recall of their products due
to their combination of Ma Huang and caffeine containing Kola Nut. Alliance later removed the caffeine containing Kola Nut and was allowed to continue to sell its new product.
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Ephedrine has moderately potent bronchial muscle relaxant properties, and
-therefore is used for symptomatic relief in milder cases of asthmatic
-attack; it is also used to reduce the risk of ac
ute attacks in the treatment
-of chronic asthma. The typical adult dose range is 30-60 mg taken orally,
-three to four times per day, in the form of tablets. Ephedrine in the form
-of nose dr
ops is also widely used to relieve nasal congestion associated
-with upper respitory tract illnesses. It is also used to treat low blood
-pressure, because it constricts blood vessels and stimul
ates certain actions
-of the heart. Common side effects are qualitatively similar to those
-produced by amphetamines and are generally milder.
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Ephedra's main active medical ingredients are the alkaloids ephedrine and pseudoephedrine. The ephedras also contain various tannins and related chemicals.The stem contains 1-3% total alkaloids, with
ephedrine accounting for 30-90% of this total. The concentrations of these alkaloids depends upon the particular species of ephedra used.
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Ephedrine is the oral form of Epinephrine, or adrenaline. It was
-once a commonly prescribed drug for asthma, but newer drugs in the
-xanthine class have less side effects.
-Ephedrine is rela
ted to pseudoephedrine which was designed as a
-decongestant with less undesirable effects.
-Ephedra is a Chinese herb that's been used for centuries to treat
-asthma
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Ephedrine alkaloids are amphetamine-like compounds used in OTC and prescription drugs with potentially lethal stimulant effects on the central nervous system and heart. The FDA has received more than
800 reports of adverse effects associated with use of products containing ephedrine alkaloid since 1994. These serious adverse effects, include hypertension (elevated blood pressure), palpitations (ra
pid heart rate), neurophathy (nerve damage), myopathy (muscle injury), psychosis, stroke, memory loss, heart rate irregularities, insomnia, nervousness, tremors, seizures, heart attacks, and death. Th
e agency has proposed to prohibit the marketing of dietary supplements containing 8 milligrams or more of ephedrine alkaloids per serving.
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The Texas Department of Health (TDH), has proposed banning certain ephedra and ephedrine-containing products made by dietary supplement companies, while preserving products of the pharmaceutical indus
try. This interesting--if a bit convoluted--proposal seeks to make the following changes in regulating products in the state of Texas:
-All ephedrine products would become prescription drugs, exce
pt:
-Ephedra (ma huang) products would be exempt only if they are less than 3% alkaloid (read "NO EXTRACTS").
-It would be illegal to sell any ephedra or ephedrine-containing product in combin
ation with combinations with caffeine or caffeine-containing plants including cola, tea or guarana.
-A list of over-the-counter (OTC) drugs made by pharmaceutical companies would be specifically e
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