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How to Use
Begin taking this medication as soon as symptoms appear. Take this medication as directed. Ask your doctor or pharmacist if you have any questions. Try to take the medication at evenly spaced interval
s throughout the day and night. This will ensure a constant blood level of the medication and is most effective.
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Proper Use of This Medicine
If you are using tablets, capsules, or liquid, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals.
If you are using ointment,
apply it as soon as you remember and apply further doses at your regular interval (e.g., every 3 hours) until you go to bed.
However, if it is almost time for the next dose, skip the missed
dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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Significant Interactions:
If Zovirax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zovirax with the fo
llowing:
- Cyclosporine (Sandimmune, Neoral)
- Interferon (Roferon-A)
- Probenecid (Benemid)
- Zidovudine (Retrovir)
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Other medical problems
Other medicines¡XAlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your do
or may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) me
dicine that is to be applied to the same area of the skin.
Other medical problems¡XTell your doctor if your herpes simplex infection keeps coming back while you are using Zovirax
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What special precautions should I follow?
This medication should be used cautiously during pregnancy only if clearly needed. It is not known if this medication appears in breast milk. Consult with your doctor before breast-feeding.
Avoid s
exual activity while signs and symptoms of genital herpes are present to prevent infecting your partner. Inform your doctor if this medication does not appear to decrease the frequency or severity of
recurrent infections.
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What side effects can this medication cause?
Parenteral:
1. Renal toxicity; precipitation of Zovirax crystals can occur in renal tubules if the maximum solubility of free Zovirax (2.5mg/ml at 37?C in water) is exceeded or if the drug is give
n by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV Zovirax manifested encephalopathic cha
nges characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; hematur
ia; hypotension; headache and nausea; thrombocytosis.
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