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Drug Interactions Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to c hange the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is t o be applied to the same area of the skin. When you are using topical Retin-A, it is especially important that your health care professional know if you are taking any of the following:

- Ac itretin (e.g., Soriatane)
- Etretinate (e.g., Tegison)
- Retin-A, oral —May increase chance of getting severe dryness or redness of skin

Why is this medication prescribed? Retin-A is used to treat acne. It works partly by keeping skin pores clear.

One of the Retin-A creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Retin-A works bes t when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by sun or the natural aging process.

Proper Use of This Medicine The presence of other medical problems may affect the use of Retin-A. Make sure you tell your doctor if you have any other medical problems, especially:
- Dermatitis, seborrheic or
- Eczema or
- Sunburn—Use of this medicine may cause or increase the irritation associated with these problems

Special warnings about this medication Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as Retin-A:

- Any other topical acne product or skin product co ntaining a peeling agent (such as benzoyl peroxide, resorcinol, salicylic acid, or sulfur)
- Hair products that are irritating, such as permanents or hair removal products
- Skin products th at cause sensitivity to the sun, such as those containing spices or limes
- Skin products containing a large amount of alcohol, such as astringents, shaving creams, or after-shave lotions
- Skin products that are too drying or abrasive, such as some cosmetics, soaps, or skin cleansers

Precautions Before Using This Medicine Before using Retin-A,

- tell your doctor and pharmacist if you are allergic to Retin-A or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medicat ions you are taking, including vitamins.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Retin-A, call your doctor.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Retin-A may make your skin sensitive to sunlight.

What side effects can this medication cause? In some animal studies, Retin-A has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other stud ies have not shown the same result and more studies need to be done. It is not known if Retin-A causes skin tumors to develop faster in humans.

Check with your doctor as soon as possible if a ny of the following side effects occur:

- Burning feeling or stinging skin (severe); lightening of skin of treated area, unexpected; peeling of skin (severe); redness of skin (severe) ; u nusual dryness of skin (severe)

- Darkening of treated skin

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