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Precautions while Using this Medicine During the first 3 weeks you are using Retin-A, your skin may become irritated. Also, your acne may seem to get worse before it gets better. It may take longer than 12 weeks before you notice full imp rovement of your acne, even if you use the medicine every day. Check with your health care professional at any time skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks .

You should avoid washing the skin treated with Retin-A for at least 1 hour after applying it.

Avoid using any topical medicine on the same area within 1 hour before or after using Retin-A. Otherwise, Retin-A may not work properly or skin irritation might occur.

Drug Interactions Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is to be applied to the same area of the skin. When you are using topical Retin-A, it is especially important that your health care professional know if you are taking any of the following:

- Acitretin (e.g., Soriatane)
- Etretinate (e.g., Tegi son)
- Retin-A, oral —May increase chance of getting severe dryness or redness of skin

Side Effects In some animal studies, Retin-A has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other stud ies have not shown the same result and more studies need to be done. It is not known if Retin-A causes skin tumors to develop faster in humans.

Check with your doctor as soon as possible if a ny of the following side effects occur:

- Burning feeling or stinging skin (severe); lightening of skin of treated area, unexpected; peeling of skin (severe); redness of skin (severe) ; u nusual dryness of skin (severe)

- Darkening of treated skin

What is this medicine Retin-A is used to treat acne. It promotes peeling of affected skin areas and unclogs pores. Retin-A controls acne but does not cure it.

What is this Drug If you are to apply any form of Retin-A, follow these steps:

- Wash your hands and affected skin area thoroughly with mild, bland soap (not medicated or abrasive soap or soap that dries the skin) and water. To be sure that your skin is thoroughly dry, wait 20-30 minutes before applying Retin-A.
- Use clean fingertips, a gauze pad, or a cotton swab to apply the medication.
- Use enough medication to cover the affected area lightly. Do not oversaturate the gauze pad or cotton swab.

Proper Use of This Medicine The presence of other medical problems may affect the use of Retin-A. Make sure you tell your doctor if you have any other medical problems, especially:
- Dermatitis, seborrheic or
- Eczema or
- Sunburn—Use of this medicine may cause or increase the irritation associated with these problems

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