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Book Review: Prozac Nation, By Elizabeth Wurtzel
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Warning
Suicide: - The possibility of a suicide attempt is inherent in depression and may persist until significant remission occurs. Therefore, high risk patients should be closely supervised throughout ther apy and consideration should be given to the possible need for hospitalization. In order to minimize the opportunity for overdosage, prescriptions for fluoxetine should be written for the smallest qua ntity of drug consistent with good patient management.


Possible food and drug interactions when taking this medication
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).


Special Wanring
Serious Adverse Reactions: - Suicidal thoughts and acts are far more common among depressed patients than in the general population. It is estimated that suicide is 22 to 36 times more prevalent in de pressed persons than in the general population. A comprehensive meta-analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder compared fluoxetine (n=1765 ) with a tricyclic antidepressant (n=731) or placebo (n=569), or both. The pooled incidence of emergence of substantial suicidal ideation was 1.2% for fluoxetine, 2.6% for placebo, and 3.6% for tricyc lic antidepressants.


Before Using This Medicine
Pregnancy¡XOne study of babies whose mothers had taken Prozac while they were pregnant found some problems in the babies, such as premature birth, jitteriness, and trouble in breathing or nursing. How ver, four other studies did not find any problems in babies or young children whose mothers had taken Prozac while they were pregnant. Tell your doctor if you are pregnant or if you may become pregnan t while you are taking this medicine.


What side effects can this medication cause?
If you experience any of the following symptoms, call your doctor immediately:

- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- persistent, fi ne tremor or inability to sit still
- fever, chills, sore throat, or flu-like symptoms
- difficulty breathing or swallowing
- severe skin rash or hives
- yellowing of the skin or e yes
- irregular heartbeat

Proper Use of This Medicine
Prozac should be taken exactly as prescribed by your doctor.

Prozac usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same time you do some other daily activity.

It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen . For obsessive-compulsive disorder, the full effect may take 5 weeks to appear.


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Directory for Prozac
Is Prozac Overly Prescribed?
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Is Prozac Overly Prescribed?
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Fda Approves Prozac For Pediatric Use To Treat Depression And Ocd
... has approved new uses for the antidepressant pro zac (fluoxetine) to treat children and adolescents seven to ... today's approval of pro zac for use in children and adolescents was based ... Prozac Online



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