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Significant Interactions:
General Anesthetics: - Since little is known about the interaction between fluoxetine and general anesthetics, fluoxetine should be discontinued for as long as clinically possible prior to elective su
rgery.
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Side Effects
In children and adolescents, less common side effects may also include:
- Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of
elation and/or rapid thoughts), nosebleeds, personality changes, and thirst
A wide variety of other very rare reactions have been reported during Prozac therapy. If you develop any new or un
explained symptoms, tell your doctor without delay.
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How to Use
Prozac should be taken exactly as prescribed by your doctor.
Prozac usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same
time you do some other daily activity.
It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen
. For obsessive-compulsive disorder, the full effect may take 5 weeks to appear.
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Precautions
Seizures:
Fluoxetine should be used with caution in patients with a history of convulsive disorders. The incidence of seizures associated with fluoxetine during clinical trials did not appear to d
iffer from that reported with other marketed antidepressants; however, patients with a history of convulsive disorders were excluded from these trials.
Concurrent administration with electro
shock therapy should be avoided because of the absence of experience in this area. There have been rare reports of a prolonged seizure in patients on fluoxetine receiving ECT treatment.
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Symptoms of overdose may include:
Any medication taken in excess can have serious consequences. An overdose of Prozac can be fatal. In addition, combining Prozac with certain other drugs can cause symptoms of overdose. If you suspect
an overdose, seek medical attention immediately.
Common symptoms of Prozac overdose include:
Nausea, rapid heartbeat, seizures, sleepiness, vomiting
Other symptoms of Prozac ov
erdose include:
Coma, delirium, fainting, high fever, irregular heartbeat, low blood pressure, mania, rigid muscles, sweating, stupor
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Adverse Effects
Allergic or Toxic:
Frequent: Rash, pruritus.
Infrequent: Chills and fever, urticaria, maculopapular rash.
Rare: Allergic reaction, erythema multiforme, vesiculobullous rash, se
rum sickness, contact dermatitis, erythema nodosum, purpuric rash, leukocytoclastic vasculitis, leukopenia, thrombocythemia, arthralgia, angioedema, bronchospasm, lung fibrosis, allergic alveolitis, l
arynx edema, respiratory distress.
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