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Other Medicines
General Anesthetics: - Since little is known about the interaction between fluoxetine and general anesthetics, fluoxetine should be discontinued for as long as clinically possible prior to elective su
rgery.
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Before Using This Medicine
Children¡XThis medicine has been tested in a limited number of children 7 to 18 years of age. These studies indicate that Prozac may help to treat depression and obsessive-compulsive disorder in child
en. However, unusual excitement, restlessness, irritability, and trouble in sleeping may be especially likely to occur in children, who seem to be more sensitive than adults to the effects of Prozac.
Prozac must be used with caution in children with depression. Studies have shown occurrences of children thinking about suicide or attempting suicide in clinical trials for this medicine. More study i
s needed to be sure Prozac is safe and effective in children.
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Drug Interactions
Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil
], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])¡XHigher blood levels of these medicines may occur, which increases the chance of having serious side e
fects. Your doctor may want to see you more often and may need to change the doses of your medicines. Also, taking amitriptyline, clomipramine, or imipramine with fluoxetine may increase the chance of
developing the serotonin syndrome
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Side Effects
If you experience any of the following symptoms, call your doctor immediately:
- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- persistent, fi
ne tremor or inability to sit still
- fever, chills, sore throat, or flu-like symptoms
- difficulty breathing or swallowing
- severe skin rash or hives
- yellowing of the skin or e
yes
- irregular heartbeat
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Symptoms of overdose
- unsteadiness
- confusion
- unresponsiveness
- nervousness
- tremor
- dizziness
- rapid, irregular, or pounding heartbeat
- seeing things or hearing voices tha
t do not exist (hallucinating)
- fever
- fainting
- coma
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Proper Use of This Medicine
Prozac should be taken exactly as prescribed by your doctor.
Prozac usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same
time you do some other daily activity.
It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen
. For obsessive-compulsive disorder, the full effect may take 5 weeks to appear.
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