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Before Taking This Medicine
Breast-feeding¡XProzac passes into breast milk. A study of 11 breast-fed babies whose mothers were taking Prozac found no effect on the babies. However, another baby whose mother was taking this medic
ne had vomiting, watery stools, crying, and sleep problems. Be sure you have discussed the risks and benefits of this medicine with your doctor.
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Adverse Effects
Neurologic:
Frequent: Headache, tremor, dizziness or lightheadedness, asthenia.
Infrequent: Abnormal gait, ataxia, akathisia, buccoglossal syndrome, hyperkinesia, hypertonia, incoordinat
ion, neck rigidity, extrapyramidal syndrome, convulsions, photophobia, myoclonus, vertigo, migraine, tinnitus, hypesthesia, neuralgia, neuropathy, acute brain syndrome.
Rare: Dysarthria, dys
tonia, torticollis, decreased reflexes, nystagmus, paralysis, paresthesia, carpal tunnel syndrome, stupor, coma, abnormal EEG, chronic brain syndrome, dyskinesia and other movement disorders (includin
g worsening of preexisting conditions or appearance in patients with risk factors neuroleptic malignant syndrome-like events.
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Drug Interactions
Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil
], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])¡XHigher blood levels of these medicines may occur, which increases the chance of having serious side e
fects. Your doctor may want to see you more often and may need to change the doses of your medicines. Also, taking amitriptyline, clomipramine, or imipramine with fluoxetine may increase the chance of
developing the serotonin syndrome
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Proper Use of This Medicine
Prozac should be taken exactly as prescribed by your doctor.
Prozac usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same
time you do some other daily activity.
It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen
. For obsessive-compulsive disorder, the full effect may take 5 weeks to appear.
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Precautions
Hypokalemia: - Self-induced vomiting often leads to hypokalemia which may lower seizure threshold and/or may lead to cardiac conduction abnormalities. Electrolyte levels of bulimic patients should be
assessed prior to initiation of treatment.
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Other Medicines
General Anesthetics: - Since little is known about the interaction between fluoxetine and general anesthetics, fluoxetine should be discontinued for as long as clinically possible prior to elective su
rgery.
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