is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.

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How should this medicine be used? The recommended starting dose of MERIDIA is 10-milligrams administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks to a total of 15-mill igrams taken once daily. The 5-milligram dose should be reserved for those patients that do not tolerate the 10-milligram dose. Blood pressure and heart rate changes should betaken into consideration when making decisions regarding dose titration. Take this medication as prescribed. Do not take it more often or longer than directed. Use in combination with other appetite suppressant medicine is ge nerally not recommended.

Before Using This Medicine Breast-feeding—It is not known whether Meridia passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. A mother w ho is taking this medicine and who wishes to breast-feed should discuss this with her doctor.

What side effects may occur? Check with your doctor as soon as possible if any of the following side effects occur:

- Achiness; chills; fast or irregular heartbeat; increased blood pressure ; mental depression; pain ful menstruation; swelling of body or of feet and ankles

- Bruising or red spots or patches on skin; convulsions (seizures); excessive bleeding following injury; headache (severe); ra pidly changing moods; skin rash; weight gain (unusual)

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which Remember that Meridia must never be taken within 2 weeks of using an MAO inhibitor such as Marplan, Nardil, or Parnate. The combination could lead to serious, even fatal, overstimulation.

Am ong the many drugs that pose a potential problem are the following:
- Fentanyl (Duragesic)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Ketoconazole (Nizoral)
- Lithium (Eska lith, Lithobid)
- Meperidine (Demerol)
- Naratriptan (Amerge)
- Paroxetine (Paxil)
- Pentazocine (Talwin NX, Talacen)
- Sertraline (Zoloft)
- Stimulants such as amphetami nes, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
- Sumatriptan (Imitrex)
- Tryptophan (L-Tryptophan)
- Venlafaxine (Effexor)
- Zolmitriptan (Zomig)

Special warnings about this medication Meridia may cause dizziness, drowsiness, or poor judgment. Be sure you know how you react to this medicine before you drive, operate machinery, or do other things that could be dangerous if you are no t alert and able to think clearly.

Meridia may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Howeve r, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth deca y, gum disease, and fungus infections.

Why is this medication prescribed? Meridia helps the seriously overweight shed pounds and keep them off. It is especially recommended for those who in addition to being overweight have other health problems such as high blood pressure, diabetes, or high cholesterol. It is used in conjunction with a low-calorie diet.

Meridia works by boosting levels of certain chemical messengers in the nervous system, including serotonin, dopamine, and norepinephrine.

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