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Drug Interactions
If Celebrex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Celebrex with the following:

- ACE-inhibitors (a type of blood pressure and heart medication, including such drugs as Capoten, Vasotec, and Prinivil)
- Blood thinning agents such as Coumadin
- Fluco nazole (Diflucan)
- Furosemide (Lasix)
- Lithium (Eskalith, Lithobid)
- Thiazide diuretics (water pills) such as hydrochlorothiazide and Dyazide

If you take low-dose aspirin t o protect against heart attack, you can continue taking it with Celebrex.

Why is this medication prescribed?
Celecoxib ( sell¡Va¡VCOKS¡Vib) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will p you only as long as you continue to take it.

Celecoxib may also be used for the following problems:

Familial adenomatous polyposis (polyps in the intestines);
Moderate or seve re pain, such as after dental or orthopedic procedures;
Pain during menstruation

How should you take this medication?
You should continue to take CELEBREX as prescribed even when you are feeling better. CELEBREX can be taken with or without food. CELEBREX capsules come in 2 strengths: 100 mg and 200 mg.

In O steoarthritis, the recommended dose for CELEBREX is 200 mg a day. CELEBREX delivers 24-hour relief from a once-daily dose of 200 mg. Or if preferred, a dose of 100 mg twice a day is available.

In Rheumatoid Arthritis, the recommended dose for CELEBREX is 100 mg to 200 mg, twice a day. CELEBREX provides relief through the day and through the night.

Precautions
Serious side effects can occur during treatment with this medicine. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Stop taki ng this medicine and check with your doctor immediately if you notice any of these warning signs.

What side effects can this medication cause?
Rare side effects may include:
- loss of appetite, loss of balance, low blood sugar, menstrual disorders, migraine headache, mouth ulcers, muscle ache, nail disorders, neck stiffness, nerve pain, nervousness, nosebleeds, pain, painful urination, pancreatitis, phlebitis, pneumonia, poor coordination, prostate problems, severe diarrhea, severe skin rash and peeling, skin reaction due to sunligh t, skin sensitivity, skin tingling, stroke, suicide, sweating, swollen face and throat, taste disturbances, tendonitis, tiredness, tooth disorders, urinary incontinence, urinary tract infections, vagi nal problems, vomiting, weakness, weight gain

Overdosage
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Symptoms of Celebrex overdose may include:
Breathing diffic ulties, coma, drowsiness, gastrointestinal bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, vomiting


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