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DRUG ABUSE AND DEPENDENCE :
When you are taking buspirone, it is especially important that your health care professional know if you are taking any of the following:

- Erythromycin (e.g., ERYC, E.E.S.) or
- Itraco nazole (e.g., Sporanox)ˇXHigher blood levels of buspirone may occur, increasing the chance of side effects. Your doctor may change the dose of buspirone that you take
- Monoamine oxidase (MAO) i ibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline at doses more than 10 mg a day [e.g., Eldepryl], tranylcypromine [e.g., Parnate])ˇX aking buspirone while you are taking monoamine oxidase (MAO) inhibitors may cause high blood pressure

Other medical problems
The presence of other medical problems may affect the use of buspirone. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease or
- Liver disease ˇXBuspirone may be removed from your body more slowly, which may increase the chance of side effects. Your doctor may need to adjust your dose

Overdosage
Any medication taken in excess can have serious consequences. If you suspect an overdose of BuSpar, seek medical attention immediately.

The symptoms of BuSpar overdose may include:
- Di zziness, drowsiness, nausea or vomiting, severe stomach upset, unusually small pupils.

Adverse Effects
Autonomic:
Dry mouth, sweating/clamminess, blurred vision, constipation. Infrequently, urinary frequency, retention and burning, flushing.
Cardiovascular:
Tachycardia, chest pain, palpita tions. Infrequently, syncope, hypotension, hypertension. Rarely, congestive heart failure, cerebrovascular accident, myocardial infarction, cardiomyopathy, bradycardia, EKG change.
Gastrointestin al:
Nausea, gastrointestinal distress, diarrhea, vomiting. Infrequently, flatulence, increased appetite, anorexia, hypersalivation, rectal bleeding, irritable colon. Rarely, burning tongue.
Re spiratory:
Nasal congestion. Infrequently, shortness of breath, chest congestion, difficulty breathing, hyperventilation. Rarely, epistaxis.

Significant Interactions:
Concomitant use of MAO inhibitors and buspirone has been reported to cause an increase in blood pressure. Therefore, concomitant use of these medications is not recommended.

Why is this drug prescribed?
Buspirone (byoo-SPYE-rone) is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. However, buspirone usually is not used for anxiety or tension caused by the stress of every day life.

It is not known exactly how buspirone works to relieve the symptoms of anxiety. Buspirone is thought to work by decreasing the amount and actions of a chemical known as serotonin in certain parts of the brain.


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